Inflammatory priming of mesenchymal stem cells: Focus on growth factors enhancement

Multipotent mesenchymal stromal cells (MSCs) are actively involved in reparation and inflammation processes, providing damaged tissue suppressing immune cell responses vivo. The effects mostly due to the production of a wide range paracrine factors, including growth factors immunomodulatory mediators. To induce immunosuppressive activity, MSCs primed by inflammatory cytokines, which results an increased molecules. However, stimulation reparative properties is also necessary. This viewpoint manuscript highlights possibilities priming increase MSCs.